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Articles

Cryo-EM structures and functional properties of CALHM channels of the human placenta

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By Marta Sawicka, Maria-Isabel Bahamonde-Santos, Zaugg Jonas, Dawid Deneka, Christiane Albrecht, Raimund Dutzler
| eLife
Abstract The transport of substances across the placenta is essential for the development of the fetus. Here, we were interested in the role of channels of the calcium homeostasis modulator (CALHM) family in the human placenta. By transcript analysis, we found the paralogs CALHM2, 4, and 6 to be highly expressed in this organ and upregulated during trophoblast differentiation.
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