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Articles by Ze Mi
Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models
Editor’s summary Glioblastoma remains the most common and aggressive adult primary brain tumor with limited effective therapies. Macrophages are key players in the glioblastoma immunosuppressive microenvironment and have the ability to infiltrate these solid tumors and interact with glioma cells. Here, Sun et al. developed an adoptive cell therapy of allogeneic macrophages loaded with ferritin-drug conjugates to deliver therapeutic payloads to glioblastoma cells.
Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice
Editor’s summary Peripheral nerve injury can lead to allodynia, a pain sensation evoked by innocuous stimuli. A disinhibition of spinal PKCγ interneurons (INs), which receive input from low-threshold mechanoreceptors but project to nociceptive circuits, is involved in the development of allodynia, but what mediates these circuit adaptations is not completely understood. Here, Zou et al.
Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion
Editor’s summary A great deal of research has aimed to improve immunogens for vaccines. However, improving immunogens alone will not necessarily result in a successful vaccine. Here, Rodrigues and Zhang et al. focused on the other half of the vaccine, the adjuvant.
Synthetic biology-driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer
Editor’s summary Mature tertiary lymphoid structures (mTLSs) are associated with better responses in colorectal cancer (CRC). In a bid to increase mTLSs to improve CRC outcomes, Mi et al. engineered an attenuated strain of Salmonella, which naturally homes to tumors to overexpress, lyse, and release TNF superfamily member LIGHT. Intragastric administration of the modified probiotic greatly reduced tumor burden in two mouse models of CRC.
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