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Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase

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By Thomas Jefferson, Abhimannyu Rimal, Zeal P. Kamdar, Chong Wai Tio
| American Society for Microbiology (ASM)
Research Article Abhimannyu Rimal, Zeal P. Kamdar, Chong Wai Tio, Edward Winter DOI: 10.1128/MCB.00097-20 ABSTRACT Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in yeast that controls spore differentiation. It is activated by a MAPK binding protein, Ssp2, upon completion of the meiotic divisions. The activation of Smk1 by Ssp2 is positively regulated by a meiosis-specific coactivator of the anaphase promoting complex (APC/C) E3 ubiquitin ligase, Ama1.
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