Zehe Ge

Abstract Glioblastoma stem cells (GSCs) are refractory to first-line treatment in the clinic, which includes irradiation (IR) and temozolomide (TMZ). Here we find that disrupting stress granules (SGs) sensitizes GSCs to IR/TMZ through ferroptosis. The profiling of SG proteins reveals the recruitment of iron-related proteins including ferritin.

Table S1. The list of antibodies used in the present study Suppl. Figure 1S. Exposure of BaP inhibits GJIC in TM4 cells. The GJIC levels were determined through scalpel loading/dye transfer assay. (A) Representative images (100×) of GJIC levels were presented when treated with different concentrations (10 μM,100 μM) of BaP for 24 h. The bright field images showed the density of cells.

Connexins (Cxs), the subunits of gap junction channels, are involved in many physiological processes. Aberrant control of Cxs and gap junction intercellular communication may contribute to many diseases, including the promotion of cancer. Cd exposure is associated with increased risk of human prostate cancer and benign prostatic hyperplasia. The roles of Cxs in the effects of Cd on the prostate have, however, not been reported previously.