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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Mutation-induced remodeling of the binding mechanism between GID4 and the PGLW peptide revealed by molecular dynamics simulations
Abstract GID4 functions as a substrate receptor in the Pro/N-degron pathway by recognizing peptides with an N-terminal proline. While the overall binding mode has been characterized, the residue-specific mechanism underlying peptide recognition remains unclear.
A bioactive peptide from the pearl has dual roles in resisting SARS-CoV-2 infection and its complications
Abstract Angiotensin-converting enzyme 2 (ACE2) is a critical receptor for the entry of the SARS-CoV-2 virus into cells. Moreover, a decrease in ACE2 level and its activity due to SARS-CoV-2 infection is considered a crucial reason for the development of Covid-19-associated complications.
Efficacy of the first bioactive peptide from the pearl
Abstract Pearls have high medicinal value. In the present study, we discovered the first bioactive peptide in pearls. The bioactive peptide, KKCHFWPFPW, was a novel angiotensin I converting enzyme (ACE) inhibitory peptide derived from the pearl matrix of Pinctada fucata. It was screened and identified using quadrupole time-of-flight mass spectrometry. The molecular weight of the peptide was 1417.5 Da, and its theoretical isoelectric point was 9.31.
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