Skip To Main Content
Zeng-Fei Pei on Muck Rack

Zeng-Fei Pei

As seen in: Nature, Cell Chemical Biology
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Zeng-Fei

Contact Zeng-Fei, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Biosynthesis of peptide–nucleobase hybrids in ribosomal peptides - Nature Chemical Biology

|
By Zeng-Fei Pei, Natalia M. Vior, Lingyang Zhu, Andrew W. Truman
| Nature Verified
Abstract The main biopolymers in nature are oligonucleotides and polypeptides. However, naturally occurring peptide–nucleobase hybrids are rare. Here we report the characterization of the founding member of a class of peptide–nucleobase hybrid natural products with a pyrimidone motif from a widely distributed ribosomally synthesized and post-translationally modified (RiPP) biosynthetic pathway.
Open in Who Shared Issue with article?

Core-dependent post-translational modifications guide the biosynthesis of a new class of hypermodified peptides - Nature Communications

|
By Zeng-Fei Pei, Lingyang Zhu, Satish K. Nair
| Nature Verified
Abstract The ribosomally synthesized and post-translationally modified peptide (RiPPs) class of natural products has undergone significant expansion due to the rapid growth in genome sequencing data. Using a bioinformatics approach, we identify the dehydrazoles, a novel class of hypermodified RiPPs that contain both side chain dehydration of Ser residues, and backbone heterocyclization at Ser, Thr, and Cys residues to the corresponding azol(in)es.
Open in Who Shared Issue with article?

Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs

|
By Kai Zhang, Zeng-Fei Pei, Min-Jie Yang
| Cell Chemical Biology Verified
Highlights • Mechercharmycin is ribosomally synthesized with complex post-translational modifications • Heterologous expression and engineering of the gene cluster afford distinct congeners • tRNAGlu-dependent regioselective dehydration is the first biosynthetic modification step Summary Mechercharmycin A (MCM-A) is a marine natural product belonging to a family of polyazole cyclopeptides with remarkable bioactivities and unique structures.
Open in Who Shared Issue with article?
See all 3 articles