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Zengbo Lu on Muck Rack

Zengbo Lu

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PLIN2-PGAM5-regulated lipid droplet-mitochondria contacts drive microglial neuroinflammation after spinal cord injury via fatty acid metabolic reprogramming

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By Daoqiang Huang, Yiqian Luo, Pan Jiang, Haojie Zhang, Longyou Xiao, Jiale He, Xuantao Hu, Senyu Yao, Limin Rong, Bin Liu, Dingzhong Cheng, Kuileung Tong, Zengbo Lu
| Nature Verified
Abstract Persistent neuroinflammation is a hallmark of central nervous system (CNS) injury, driving neuronal loss and functional deficits. While microglial lipid metabolic reprogramming, particularly lipid droplet accumulation, has been implicated in chronic inflammation, the underlying mechanisms remain poorly understood.
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