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Zengfei Xia

As seen in: Nature, MDPI
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Articles

Olverembatinib, a novel BCR-ABL tyrosine kinase inhibitor, exhibits anti-tumor activity and synergizes with gemcitabine in pancreatic ductal adenocarcinoma

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By Zengfei Xia, Fan Luo, Jing Yang, Shan Shi, Jiaxing Cao, Miaozhen Qiu, Lin Zhang, Wenlong Guan, Dajun Yang, Runduan Lin, Qiuyun Luo
| Nature Verified
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases with few treatment options. The aberrant activation of SRC PDAC suggests it as a promising therapeutic target. Here, we evaluated the antitumor activity of olverembatinib, a novel multi-target tyrosine kinase inhibitor, as a single agent and in combination with gemcitabine, the standard chemotherapeutic backbone for PDAC treatment.
Open in Who Shared Issue with article?

A Comprehensive Pan-Cancer Analysis of the Regulation and Prognostic Effect of Coat Complex Subunit Zeta 1

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By Yuting Sun, Yingxia Lan, Zengfei Xia, Tian Di
| MDPI
Abstract : The Coatomer protein complex Zeta 1 (COPZ1) has been reported to play an essential role in maintaining the survival of some types of tumors. In this study, we sought to explore the molecular characteristics of COPZ1 and its clinical prognostic value through a pan-cancers bioinformatic analysis.
Open in Who Shared Issue with article?
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