Zengmiao Wang

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Wang Z, Zhou Z, Wang J, Yang L, Zhang Z, Xu W, et al. (2026) Characterization of the heterogeneity in SARS-CoV-2 fitness dynamics via graph representation learning. PLoS Comput Biol 22(1): e1013582.

eLife assessment The study by Zhu et al. provides important insights into cell-specific genome-wide histone modifications in the frontal cortex of individuals with schizophrenia, as well as shedding light on the role of age and antipsychotic treatment in these associations. The evidence supporting the conclusions is solid.

Discussion Distinct from the previous analyses, we showed for the first time that DNA motifs can be predictive of regional somatic mutation rates at the kilobase scale. The DNA motifs include known TF motifs as well as epi-motifs that are associated with histone modifications or DNA methylation. We showed that the prediction performance is comparable to that using histone and TF ChIP-seq data.