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Zengshuo Mo

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Articles

The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency

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By Mingchong Yang, Kelly Walsh, Wen Liu, Imane Nait Irahal, Damien Arnoult, Xiaoyan Guo, Zengshuo Mo
| Nature Verified
Abstract Mitophagy is crucial for maintaining mitochondrial health, but how its levels adjust to different stress conditions remains unclear. In this study, we investigated the role of the DELE1-HRI axis of the integrated stress response (ISR) in regulating mitophagy, a key mitochondrial quality control mechanism.
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