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Zening Dong

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Cellular senescence and SASP in tumor progression and therapeutic opportunities - Molecular Cancer

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By Yu Tian, Tianqiang Jin, Feng Xu, Zening Dong, Yahan Luo, Zhangchen Yuan
| Molecular Cancer Verified
The SASP plays a dual role in tumor biology due to its heterogeneity. SASP can act as both a tumor suppressor and a promoter of tumor initiation and progression. On one hand, SASP is known to enforce cell cycle arrest and recruit immune cells to eliminate damaged or oncogene-expressing cells, acting as a protective mechanism against tumorigenesis. On the other hand, SASP can create an immunosuppressive environment that supports tumor progression and recurrence.
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