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Zeren Yin on Muck Rack

Zeren Yin

As seen in: Nature
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Articles

Hepatocyte IRE1α–XBP1s axis prevents pro-metastatic niche formation through metabolic rewiring of inflammatory monocytes

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By Haiyan Zhang, Peibin Liang, Wei Yang, Xiaocong Chen, Yizhen Fu, Chonghao Chen, Xiaolin Li, Xin Pei, Josh Haipeng Lei, Xiangpeng Chu, Zhi-bin Zhao, Hai Hu, Minshan Chen, Hong Pan, Zhe-Xiong Lian, Xiaofan Ding, Nils Halberg, Grant A. Ramm, Jiajie Hou, Zeren Yin
| Nature Verified
Abstract Inositol-requiring enzyme 1α (IRE1α) and the downstream spliced form of X-Box Binding Protein 1 (XBP1s) have been identified as tumor promotors. However, how IRE1α–XBP1s signaling affects tumor progression in a non-cell autonomous manner remains unclear. Here we show that the hepatocyte IRE1α–XBP1s axis unexpectedly inhibits liver metastasis by confining local metainflammation.
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