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Zesuliwe Jule

As seen in: Nature, medRxiv
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Articles

Host proteins associated with strong neutralizing SARS-CoV-2 antibody responses in a South African cohort - Communications Medicine

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By Afrah Khairallah, Zesuliwe Jule, Alice Piller, Mallory Bernstein, Kajal Reedoy, Yashica Ganga, Sashkia R. Balla, Prudence Kgagudi, Bernadett I Gosnell, Farina Karim, Mahomed-Yunus S. Moosa, Thumbi Ndung’u, Thandeka Moyo-Gwete, Penny Moore, Khadija Shafaat Khan, Alex Sigal
| Nature Verified
Abstract Severe Covid-19 leads to higher neutralizing antibody levels, a key correlate of protection. However, the host proteins associated with this response have not been fully characterized. We asked which proteins in the blood plasma associate with neutralization, anti-spike antibody levels, and disease severity in a South African cohort upon first SARS-CoV-2 exposure.
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Severe disease is not essential for a high neutralizing antibody response post-SARS-CoV-2 infection

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By Afrah Khairallah, Zesuliwe Jule, Mallory Bernstein, Alice Piller
| medRxiv
Alex Sigal has received an honorarium from Pfizer for consultation. This study was supported by the Bill and Melinda Gates award INV-018944 and the National Institute of Health award 5R01AI138546-05 (AS). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Open in Who Shared View Duplicates (19) Issue with article?

Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant

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By Khadija Shafaat Khan, Gila Lustig, Kajal Reedoy, Zesuliwe Jule
| medRxiv
Methods Blood samples and nasopharyngeal swab for ancestral D614G SARS-CoV-2 isolation were obtained after written informed consent from adults with PCR-confirmed SARS-CoV-2 infection who were enrolled in a prospective cohort study at the Africa Health Research Institute approved by the Biomedical Research Ethics Committee at the University of KwaZulu–Natal (reference BREC/00001275/2020).
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