Zexia Zhao on Muck Rack

Zexia Zhao

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Articles

Hypoxia-induced MIC19 myristoylation promotes PRKN-dependent VDAC2 ubiquitination and activates mitophagy in non-small cell lung cancer

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By Hua Huang, Chen Ding, Wenhao Zhao, Guorui He, Hongbing Zhang, Peijie Chen, Yongwen Li, Hongyu Liu, jun chen, Zexia Zhao
| Nature Verified
Abstract Tumor hypoxia drives mitophagy reprogramming to support mitochondrial quality control in non-small cell lung cancer (NSCLC) cells, yet the role of the mitochondrial cristae organizers remains poorly understood. Here, we identified MIC19, a key subunit of mitochondrial contact site and cristae organizing system complex, as an essential regulator of hypoxia-induced mitophagy in NSCLC.
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