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Forging the tricyclic core framework of euphordraculoate B via a Barbier-type allyl addition
Forging the tricyclic core framework of euphordraculoate B via a Barbier-type allyl addition A novel strategy for the synthesis of an advanced intermediate en route to the tigliane derivative euphordraculoate B was described, which led to the successful construction of the 5/5/6 tricyclic core framework as well as the multiple consecutive stereocenters on the skeleton. Key steps of the strategy include a chlorination reaction, an aldol reaction, and a Barbier-type allyl addition.
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