Zhanat Koshenov on Muck Rack

Zhanat Koshenov

As seen in: Nature, BioRxiv
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Articles

Presenilin-1 controls glycolysis and identity of pancreatic beta cells

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By Zhanat Koshenov, Sandra Postić, Furkan E. Oflaz, Oleksandra Tiapko, Benjamin Gottschalk, Martin Hirtl, Yusuf C. Erdogan, Johannes Pfabe, Bernhard Hochreiter, Matthias Schittmayer, Jelena Tadić, Barbara Ehall, Frank Madeo, Tobias Madl, Roland Malli, Ruth Birner-Gruenberger, Thomas R. Pieber, Tobias Eisenberg, Marjan Slak Rupnik, Wolfgang F. Graier, Gabriela Schoiswohl, Savina van Amsterdam, Victoria Hois-Zelinka, Rene Rost, Olaf G. Bachkoenig, Aigerim Koshenova, Adlet Sagintayev, Anita Krnjic, Srdjan Sarikas, Juergen Gindlhuber
| Nature Verified
Abstract Presenilin-1 (PS1) is an endoplasmic reticulum protein, most known for its role in pathogenesis of familial Alzheimer’s Disease (AD). PS1 has been attributed roles in intracellular calcium homeostasis in the brain, as well as in the pancreatic beta cells, where it has been shown to be fundamental for the initial phase of glucose-induced insulin secretion.
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Hexokinase 1 forms rings that constrict mitochondria during energy stress

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By Benjamin Gottschalk, Benjamin Bourgeois, Johannes Pilic, Zhanat Koshenov
| BioRxiv
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