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Zhangliang Cheng

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Articles

Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia

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By Zhenbo Tu, Jaewoong Lee, John Foley Verified, Ruifeng Sun, Kohei Kume, Mark Robinson, Kadriye Nehir Cosgun, Ning Ma, Christian Hurtz, Huimin Geng, Selina M. Luger, Mark Litzow, Elisabeth Paietta, Jianjun Chen, Nagarajan Vaidehi, Markus Müschen, Zhangliang Cheng
| Science Magazine Verified
Editor’s summary Although CD25 is a subunit of the IL-2 receptor on T cells, CD25-expressing cells in the leukemias B-ALL and AML do not respond to IL-2 and are associated with poor clinical outcome. Through experiments with mice and patient-derived xenografts, Lee et al. showed that loss of CD25 in acute leukemia resulted in hyperactive oncogenic tyrosine kinase signaling that reduced cell fitness and leukemic potential.
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