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Zhangquan Ying on Muck Rack

Zhangquan Ying

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Articles

Arachidonate lipoxygenase 5 metabolism axis promoting ferroptosis: a potential druggable target for doxorubicin-induced cardiomyopathy

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By LU CHEN, Xingang Sun, Han Zhang, Xuan Zhang, Zuoshi Wen, Chenxi Li, Mengjia Chen, Shuai Yuan, Liangrong Zheng, Ting Chen, Mairedan Muhetarijiang, Zhangquan Ying
| Nature Verified
Abstract Doxorubicin (Dox) is a widely-used anthracycline drug for various cancers, but its clinical application is limited due to cardiotoxicity. Targeting ferroptosis is a new and effective strategy for treating Dox-induced cardiomyopathy (DIC). The arachidonate lipoxygenase 5 (ALOX5) metabolism axis is closely linked to ferroptosis, but its role in DIC remains unknown.
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