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Submitted: 16 October 2026 You are already at the latest version Mosquitoes transmit a wide range of human pathogens, including Plasmodium parasites and arboviruses. Insects rely primarily on pattern recognition receptors (PRRs) to initiate innate immunity against invading pathogens. Leucine-rich repeat proteins (LRRPs), such as LRIM1 and APL1, are critical PRRs that mediate anti- Plasmodium immunity in Anopheles mosquitoes.
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