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Introduction The knee joint has a complicated microenvironment consisting of many types of cells, such as osteocytes, hematopoietic stem cells, chondrocytes, synovial cells, nerve cells, and fat cells. Osteoarthritis (OA) is a progressive and heterogeneous disease that contributes to articular cartilage degeneration, alterations in subchondral bone, and synovial hyperplasia (Allen and Golightly, 2015; Martel-Pelletier et al., 2016).
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