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1 Introduction Xylene is a colorless aromatic volatile organic compound (VOC) that is widely used as a solvent and chemical feedstock in industrial manufacturing, pharmaceuticals, and explosives production [1]. However, xylene is highly toxic, and prolonged or excessive exposure can cause severe adverse effects to human health, including respiratory irritation, central nervous system depression, and hematological disorders.
The current study integrates formation enthalpy and traditional slurry experiments to quickly assess the physical stability of cocrystal drug substance candidates for their potential to support drug development. Cocrystals of an antidiabetic drug (GKA) with nicotinamide (NMA), vanillic acid (VLA), and ethyl vanillin (EVL) were prepared and characterized by powder X-ray diffractometry (PXRD), spectroscopic, and thermal techniques.
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