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Zhaoqing Yin

As seen in: Nature
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Articles

TRIM32-mediated ubiquitination of STING promotes glycolysis and tumor progression

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By Huaxin Zhou, Zhengyao Guan, Zhaoqing Yin, Biaofeng Shan, Jun Wu, Kangping Lu, Jiazheng Li, Hao Zhang, Jianyun Wang, Chongzhong Liu, Xiangyu Zhai, Zhangshuo Yang
| Nature Verified
Abstract The Warburg effect, a hallmark of metabolic reprogramming, drives tumor progression, but its upstream regulation remains unclear. Using hepatocellular carcinoma (HCC) as a model, we identify TRIM32, an E3 ubiquitin ligase, as a potent activator of glycolysis that promotes malignancy. TRIM32 is upregulated in HCC tissues and cell lines, correlating with aggressive features and poor prognosis.
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Correction: MYCBP2-mediated HNF4α ubiquitination reprogrammed lipid metabolism in MASH-associated hepatocellular carcinoma

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By Hao Zhang, Xiangxu Kong, Haoran Qu, Yi Gao, Huaxin Zhou, Zhaoqing Yin, Wei Wang, Xiangyu Zhai, Bin Jin, Zhengyao Guan, Kangping Lu
| Nature Verified
Correction to: Oncogene https://doi.org/10.1038/s41388-025-03373-5, published online 03 April 2025 During a recent review of our published paper, we noticed an inadvertent error in Figure 5L. When assembling the figure panels, a duplicate graph was unintentionally placed in the statistical graph section for the colony formation assay.
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Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing

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By Huijun Wang, Xinran Dong, Feifan Xiao, Yulan Lu, Mengyuan Qiao, Bingbing Wu, Qi Ni, Kai Yan, Qin Li, Zhaoqing Yin, Dongmei Chen, Liping Chen, Wenqing Kang, Qiufen Wei, Li Tao, Guoqiang Cheng, Laishuan Wang, Kai Li, Chun Shen, Sujuan Wang, Xiu ling Xu, Mingqi Yang, Fei Liu, Kang Zhang, Wenhao Zhou
| Nature Verified
Abstract Next-generation sequencing technologies have been widely applied in diagnosing genetic disorders in pediatric patients. However, the cancer predisposition and tumor characteristics in individuals who have germline pathogenic variants remain unclear. We analyzed exome sequencing data from 75,602 pediatric patients referred for genetic testing between January 2016 and January 2025, tracking cancer as a secondary finding.
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