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Zhaoqing Yin

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Articles

Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing

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By Huijun Wang, Xinran Dong, Feifan Xiao, Yulan Lu, Mengyuan Qiao, Bingbing Wu, Qi Ni, Kai Yan, Qin Li, Zhaoqing Yin, Dongmei Chen, Liping Chen, Wenqing Kang, Qiufen Wei, Li Tao, Guoqiang Cheng, Laishuan Wang, Kai Li, Chun Shen, Sujuan Wang, Xiu ling Xu, Mingqi Yang, Fei Liu, Kang Zhang, Wenhao Zhou
| Nature Verified
Abstract Next-generation sequencing technologies have been widely applied in diagnosing genetic disorders in pediatric patients. However, the cancer predisposition and tumor characteristics in individuals who have germline pathogenic variants remain unclear. We analyzed exome sequencing data from 75,602 pediatric patients referred for genetic testing between January 2016 and January 2025, tracking cancer as a secondary finding.
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