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ZheChu Xuan

As seen in: Frontiers
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Articles

Biomimetic dexamethasone-loaded nanoparticles attenuate sepsis-induced acute lung injury

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By Chunna Jin, Nan Zheng, YuMeng Liu, Zheng Wu, Jian Shen, Huijun Liang, LiuGuang Song, ZheChu Xuan
| Frontiers
Abstract Background: Sepsis-induced acute lung injury (ALI) is a severe complication characterized by uncontrolled inflammation and high mortality, yet effective targeted therapies remain limited. Notably, acute myocardial infarction (MI) frequently coexists with or exacerbates ALI through shared inflammatory pathways. Dexamethasone (Dex) exerts potent anti-inflammatory effects but its clinical application is limited by non-specific biodistribution and dose-dependent off-target toxicities.
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