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Zhenfa Zhang on Muck Rack

Zhenfa Zhang

As seen in: Environmental Health Perspectives, Nature, Wiley Online Library, The BMJ, Royal Society of Chemistry, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles

Neoadjuvant retlirafusp alfa (anti-PD-L1/TGF-β bifunctional fusion protein) with or without chemotherapy in unresectable stage III non-small cell lung cancer: updated results from the phase 2 TRAILBLAZER trial

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By Yi Pan, Xuening Yang, Qing Zhou, Yanqiu Zhao, Guang Han, Qingsong Pang, Zhenfa Zhang, Qifeng Wang, Jun Yao, Hui Wang, Weihua Yang, Baogang Liu, Qixun Chen, Xianghui Du, Kaican Cai, Baosheng Li, Yunchao Huang, Xiao Li, Yijun Jia, Wei Shi, Yi-Long Wu
| Nature Verified
Abstract TRAILBLAZER is a proof-of-concept phase 2 study (ClinicalTrials.gov, NCT04580498) of neoadjuvant retlirafusp alfa (an anti-PD-L1/TGF-β bifunctional agent) in unresectable stage III non-small cell lung cancer (NSCLC) not harboring EGFR or ALK alterations. During induction, retlirafusp alfa was administered either with chemotherapy or as monotherapy, followed by surgery or radiotherapy as assessed by a local multidisciplinary team and consolidation retlirafusp alfa.
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Activity-guided substructure prioritization accelerates discovery of gut microbiota-derived immune-regulating metabolites

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By Haoduo Zhao, Zhenfa Zhang, Yun-Chung Hsiao, Chih-Wei Liu, YIFEI YANG, R. Balfour Sartor, Kun Ping Lu
| Nature Verified
Abstract Gut microbiota exert significant influences on host physiology through bioactive molecules such as indole derivatives. The characteristic aromatic heterocycle substructure shared among various indole derivatives is intrinsically associated with the activation of aryl hydrocarbon receptor (AhR), suggesting a potential structure-activity relationship (SAR).
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Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma

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By Lianmin Zhang, Yanan Cui, Guangyao Zhou, Zhenfa Zhang
| The BMJ Verified
Method The transcriptomic, copy number variation (CNV), mutation, H&E slides, and clinical data of LUAD were successfully retrieved from The Cancer Genome Atlas (TCGA) database (https://portal.gdc.cancer.gov) and used as the training set for model construction.
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