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Zhengzhou Ying

As seen in: BioRxiv, Texas Medical Center
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Articles

"Enhanced CD19 Activity in B Cells Contributes to Immunodeficiency in M" by Zhengzhou Ying, Swanand Hardikar et al.

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By Zhengzhou Ying, Swanand Hardikar, Joshua Plummer, Tewfik Hamidi
| Texas Medical Center
Abstract Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder characterized by DNA hypomethylation and antibody deficiency. It is caused by mutations in DNMT3B, ZBTB24, CDCA7, or HELLS. While progress has been made in elucidating the roles of these genes in regulating DNA methylation, little is known about the pathogenesis of the life-threatening hypogammaglobulinemia phenotype.
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Author Correction: Enhanced CD19 Activity in B Cells Contributes to Immunodeficiency in Mice Deficient in the Icf Syndrome Gene Zbtb24

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By Zhengzhou Ying
| Texas Medical Center
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The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA

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By Swanand Hardikar, Ren Ren, Zhengzhou Ying, John Horton
| BioRxiv
Abstract CDCA7, encoding a protein with a C-terminal cysteine-rich domain (CRD), is mutated in immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome, a disease related to hypomethylation of juxtacentromeric satellite DNA. How CDCA7 directs DNA methylation to juxtacentromeric regions is unknown. Here, we show that the CDCA7 CRD adopts a unique zinc-binding structure that recognizes a CpG dyad in a non-B DNA formed by two sequence motifs.
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