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Articles by Zhenjun Li
Compartmental immune responses and biomarker discordance after neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
Abstract Neoadjuvant chemoimmunotherapy can produce uneven responses across the primary tumour, regional lymph nodes, and occult systemic disease. Pathology, circulating tumour DNA (ctDNA), and imaging capture different consequences of this response, so their disagreement can contain clinically relevant biological information.
Tyrosine-protein phosphatase non-receptor type 2 deficiency in macrophages diminishes the anti-inflammatory and cardioprotective effects of gabapentin after myocardial infarction
CONFLICT OF INTEREST STATEMENT All authors declare no conflict of interest. DATA AVAILABILITY STATEMENT The primary data of the current study are available from the corresponding author on reasonable request. Supporting Information Filename Description bph70609-sup-0001-Figures S1-S4.pdfPDF document, 1.3 MB Figure S1 GBP treatment promotes PTPN2 expression, and GBP treatment following MI modelling is also effective in alleviating MI in mice.
Biodiversity and emerging infectious threats: the microbial dark matter of Southwest China
Abstract Southwest China is a global biodiversity hotspot, and its complex and diverse ecosystems harbor vast amounts of “microbial dark matter.” This paper systematically examines the distribution characteristics of microbial dark matter in hosts such as arthropods, mammals, and birds, as well as in environments including soil, hot springs, and high-altitude lakes, with a particular focus on the cross-species transmissibility and pathogenic potential of emerging pathogens.
ITK-targeted immune remodeling enhanced the efficacy of anti-CD19 CAR-T cell therapy - Cell Death Discovery
Abstract Despite the promising efficacy of anti-CD19 CAR-T cells in treating B-cell lymphoma, T cell dysfunction and exhaustion remains a critical barrier to achieving durable responses. Based on the immunomodulatory effect in the clinical trial enrolled lymphoma patients, this study aims to explore the potential of the first in class highly selective ITK inhibitor soquelitinib in enhancing the persistence and antitumor functionality of CAR-T cells.
When LLM Agents Meet Graph Optimization: An Automated Data Quality Improvement Approach
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Deep Reinforcement Learning-Based Motion Control Optimization for Defect Detection System
1. Introduction Since the 20th century, deep-sea environments have attracted extensive exploration due to their abundant natural resources and high scientific value. Ensuring the structural integrity of manned deep-sea vehicles in such harsh conditions is critical. In our previous research, we developed an X-ray defect detection system for weld seams in manned spherical shells.
Interface modification of hole transport layer in tin-based halide perovskite solar cells
Interface modification of hole transport layer in tin-based halide perovskite solar cells PEDOT:PSS is one of the most widely used hole transport materials in tin-based perovskite solar cells. However, the acid residues in the PEDOT:PSS caused chemical/physical reactions with the ITO electrode.
EFR-FCOS: enhancing feature reuse for anchor-free object detector
EFR-FCOS: enhancing feature reuse for anchor-free object detector School of Information and Communications Technology, Shenzhen City Polytechnic, Shenzhen, Gangdong, China DOI 10.7717/peerj-cs.2470 Academic Editor Xiangjie Kong Subject Areas Algorithms and Analysis of Algorithms, Artificial Intelligence, Computer Vision, Neural Networks Keywords EFR-FCOS, GANet, AFF-FPN, EnHead, Object detection Copyright © Licence This is an open access article distributed under the terms of the Creative...
Mechanical Properties and Stress-Strain Relationship of PVA-Fiber-Reinforced Engineered Geopolymer Composite
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Probabilistic Models for the Shear Strength of RC Deep Beams
5.3. Continuity and Uncertainty The consistent performance and model uncertainty concerning essential variables were investigated by comparing test and model results. The boxplots of the experiment-to-prediction ratios were made for different ranges of each of the following key explanatory terms: fc′ (Figure 6a), a/d (Figure 6b), b/h (Figure 6c), and ρ (Figure 6d). The boxplots of the bias of the proposed model, ACI 318-14, and the modified probabilistic model were made for comparison.
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