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Articles by Zhenyi Su
Metabolites and cancer metastasis
Abstract Over the past decades, metastasis research has largely emphasized genetic and epigenetic regulators. Emerging evidence indicates that metabolites—including sugars (glucose, fructose), antioxidant vitamins, glutathione, lipids (palmitic acid, cholesterol), and amino acids (glutamine, aspartate, BCAAs)—can critically influence metastasis in a context-dependent manner by driving or restraining progression via metabolic reprogramming and signaling modulation.
TNFAIP3‐interacting protein 1 (ABIN‐1) negatively regulates caspase‐8/FADD‐dependent pyroptosis
Conflicts of interest The authors declare that they have no conflicts of interest. References 1 & (2024) A guide to cell death pathways. Nat Rev Mol Cell Biol 25, 379–395. 2 & (2022) No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death. Biochem J 479, 1083–1102. 3, & (2016) The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases. Nat Rev Rheumatol 12, 543–558.
An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription
Research Article BIOCHEMISTRY Zhenyi Su https://orcid.org/0000-0001-5557-6750, Yanqing Liu https://orcid.org/0000-0002-3520-1887, [...] , Zhangchuan Xia https://orcid.org/0000-0002-1176-0027, Anil K. Rustgi, and Wei Gu https://orcid.org/0000-0002-1480-2368 wg8@cumc.columbia.edu+2 authors fewerAuthors Info & Affiliations Abstract We have found that the ketogenic (Keto) diet is able to, unexpectedly, promote the metastatic potential of cancer cells in complementary mouse models.
Mutant p53 on the Path to Metastasis
Gupta G.P. Massagué J. Review cancer metastasis: building a framework. Cell. 2006; 127: 679-695 Lambert A.W. et al. Review emerging biological principles of metastasis. Cell. 2016; 168: 670-691 Powell E. et al. Contribution of p53 to metastasis. Cancer Discov. 2014; 4: 405-414 Alderton G.K. Tumour evolution: epigenetic and genetic heterogeneity in metastasis. Nat. Rev. Cancer. 2017; 17: 141 Kandoth C. et al. Mutational landscape and significance across 12 major cancer types. Nature. 2013; 502: 333-339 Rivlin N.
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC
This work was supported in part by grants (to J.Y.) from the NINDS (1R01NS082257) and the NIA (1R01AG047231) and from the Chinese Academy of Sciences, the China Ministry of Science and Technology Program (2014ZX09102001-002), the China National Natural Science Foundation (31530041), the National Key R&D Program of China, and the National Key Research and Development Program (2016YFA0501900). We thank V.
LncRNA: a versatile regulator of the NF-κB signaling circuit
The Nuclear Factor-?B (NF-?B) family of transcription factors play an essential role for the regulation of inflammatory responses, immune function and malignant transformation. Aberrant activity of this signaling pathway may lead to inflammation, autoimmune diseases and oncogenesis. Over the last two decades great progress has been made in the understanding of NF-?B activation and how the response is counteracted for maintaining tissue homeostasis.
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