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Zhenying Shang

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Articles

Long‐Term Minocycline Treatment Exhibits Enhanced Therapeutic Effects on Ischemic Stroke by Suppressing Inflammatory Phenotype of Microglia Through the EMB/MCT4/STING Pathway

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By Shangqi Liu, Ling Gao, Ning Xin, Zhenying Shang
| Wiley Online Library Verified
1 Introduction Stroke is the second leading cause of adult mortality worldwide, with ischemic stroke accounting for approximately 84% of all strokes [1]. Excessive activation of microglia after stroke exacerbates neuroinflammatory damage [1, 2]. Current treatments for ischemic stroke mainly rely on thrombolysis with drugs such as rt-PA and physical thrombectomy [3, 4], with limited options to alleviate poststroke neuroinflammatory damage, significantly affecting patient prognosis [5].
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