Zhirou Li on Muck Rack

Zhirou Li

As seen in: Nature
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Graph neural network modeling of spatial tumor-immune interactions identifies prognostic cellular niches in non‑small cell lung cancer - npj Precision Oncology

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By Katharina V. Hoebel, James Lindsay, Jennifer Altreuter, Joao V Alessi, Jason L. Weirather, Ian D Dryg, Anita Giobbie-Hurder, Kun-Hsing Yu, Mark Awad, Scott J. Rodig, William Lotter, Zhirou Li
| Nature Verified
Abstract The spatial organization of immune and tumor cells within the tumor microenvironment (TME) has a critical influence on antitumor immunity and patient survival. However, hand-engineered metrics such as cell densities or pairwise proximity scores fail to capture the complexity of local cell-cell interactions. Understanding these higher-order spatial patterns and their relation to patient outcomes is especially important for non-small cell lung cancer (NSCLC), the deadliest cancer worldwide.
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