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Zhixiong Su on Muck Rack

Zhixiong Su

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Articles

CAF-derived TGF-β1 activates an LBH-mediated β-catenin stabilization program to drive gastric cancer progression

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By Guifeng Zhang, Jiangming Zhong, Lijie You, Yufang He, Jingbo Chen, Zhenhua Liu, Zhixiong Su
| Nature Verified
Abstract Aberrant Wnt/β-catenin signaling is frequently observed in gastric cancer (GC); however, the mechanisms sustaining this pathway in the absence of canonical genetic mutations remain incompletely understood. Here we show that the transcriptional cofactor LBH drives mutation-independent Wnt activation and malignant progression in GC via a tumour microenvironment-regulated post-translational stabilization mechanism.
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