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Zhiyin Song

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Articles

Mitochondrial-derived vesicles drive budding-type fission of damaged lysosomes

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By Jianglong Yu, Zhuofan Li, Le Jiang, Chen Huang, Zhouyi Rong, Long Lin, Yueguang Rong, Chaojun Yan, Zhishui Chen, Jingfeng Tang, Anbing Shi, Yuanchun Luo, Zhiyin Song
| Nature Verified
Abstract Lysosomes are central degradative organelles essential for cellular homeostasis, yet the mechanisms that maintain their integrity and function under stress remain incompletely understood. Here we identify a previously unrecognized lysosomal renewal process, termed budding-type fission (B-fission), which restores lysosomal function during hypoxia–reoxygenation stress.
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