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Beyond extremophiles: conserved molecular toolkits enable the resilience of human-associated microbes to Martian stressors
Abstract The inevitable introduction of human-associated microbes on Mars poses significant planetary protection risks, yet the survival potential of non-extremophiles under surface conditions remains ill-defined. We evaluated the resilience of three common gut bacteria—Enterococcus faecalis, Serratia liquefaciens, and Escherichia coli—under simulated Martian stressors including low pressure, CO₂-rich atmosphere, and perchlorate exposure, applied individually and in combination.
Prognostic significance of the endothelial activation and stress index in acute respiratory distress syndrome: a retrospective cohort study
Abstract Endothelial cells play a crucial role in the pathogenesis of acute respiratory distress syndrome (ARDS). The Endothelial Activation and Stress Index (EASIX) is regarded as a reliable biomarker of endothelial dysfunction. The aim of this study was to evaluate the prognostic value of baseline and dynamic EASIX trajectories in ARDS patients. The data of this study were sourced from the Medical Information Mart for Intensive Care IV (MIMIC-IV) 2.2 database.
Diagnostic Accuracy of Screening Tools for Delirium in Adults Receiving Care in Intensive Care Units: A Systematic Review and Network Meta-Analysis
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description nhs70344-sup-0001-PRISMAchecklist.docWord document, 27 KB Data S1: nhs70344-sup-0001-PRISMAchecklist.doc. nhs70344-sup-0002-Supinfo.docWord document, 719.9 KB Data S2: nhs70344-sup-0002-Supinfo.doc. eFigure 1.
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