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Circulating metabolite signatures mediating the association between minerals in domestic water and incident MASLD: a prospective cohort study
Abstract Background: Epidemiological evidence on minerals in domestic water and incident metabolic dysfunction-associated steatotic liver disease (MASLD) remains limited, particularly regarding potential mediating roles of circulating metabolites. We evaluated the association between minerals and incident MASLD and characterized metabolomic biomarkers that may mediate this association. Methods: We included 218,339 UK Biobank participants without MASLD or other liver disease at baseline.
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