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miR-22-3p靶向GSDMD抑制同型半胱氨酸诱导的平滑肌细胞焦亡

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By Ding Ning, Wang Yichen, Liu Chao, ZHONG Yingyi
| zgsydw.cnjournals.com
Abstract: Objective To investigate the effect of miR-22-3p on pyroptosis of vascular smooth muscle cells (VSMCs) induced by homocysteine (Hcy). Methods Human VSMCs were cultured in vitro and divided into a Control group (0 μmol/L Hcy) and a Hcy group (100 μmol/L Hcy). After intervention, expression levels of pro Caspase-1,gasdermin D (GSDMD), N-GSDMD, and NLR family pyrin domain containing 3 (NLRP3) were detected by Western blot.
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