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Zhongke Yin

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Articles

Functional cooperation between LIPI-4 and listeriolysin O governs intracellular replication and systemic virulence of Listeria monocytogenes

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By Zhijie Luo, Xun Ma, Caixia Liu, Lu Liu, Jing Wang, Guangdong Hu, Zhongke Yin, Yatao Qi, Ruixuan Qian
| Frontiers
Abstract Background: Listeria monocytogenes (L. monocytogenes) is a facultative intracellular bacterium and the etiological agent of listeriosis, an invasive infection that disproportionately affects neonates, older adults, pregnant women, and immunocompromised individuals. Among the major virulence determinants of L. monocytogenes, listeriolysin O (LLO) and the pathogenicity island LIPI-4 have been implicated in intracellular survival and tissue tropism.
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