Zhongming Huo

Open Access Dilshoda Alimova, Bakhtiyar Khudayarov, Kudrat Ruzmetov, Fozilzhon Turaev, Nigora Safarbayeva, Orzugul Bozorova, Maftuna Sa’dullayeva and Xasanbek Nazarov Published online: 14 November 2024

1 Introduction Omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), particularly eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA), are well considered as physiologically essential nutrients that have beneficial effects on human health (Djuricic and Calder, 2021). They play crucial roles, especially in neurological development, inflammatory response, and mitigating several diseases (Sijben and Calder, 2007; Gould et al., 2013; Marventano et al., 2015).

Introduction The COMMD (copper metabolism gene MuRR1 domain) family includes ten evolutionarily conserved proteins, namely, COMMD1–10, in the extreme carboxyl terminus of which they share a unique motif known as the COMM domain (Burstein et al., 2005). The COMM domain, with 70–85 amino acids in length and being rich in tryptophan, proline, and leucine, not only defines the gene family but also provides a critical interface for protein–protein interactions with each other (Maine et al., 2007).