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Back to Journals » Diabetes, Metabolic Syndrome and Obesity » Volume 17 Letter Diabetes Pathophysiology and Complications Authors Luo Y, Huang Z, Yang J Received 20 November 2024 Accepted for publication 26 November 2024 Published 28 November 2024 Volume 2024:17 Pages 4571—4572 DOI https://doi.org/10.2147/DMSO.S507669 Checked for plagiarism Yes Editor who approved publication: Prof.
Highlights • scChaRM-seq enables single-cell multi-omics analyses of human oocytes • There is extensive de novo DNA methylation in growing human oocytes • Transcription and chromatin accessibility correlate with de novo DNA methylation • Comparative analyses reveal distinct molecular layers between human and mouse oocytes Summary Developing female human germ cells undergo genome-wide epigenetic reprogramming, but de novo DNA methylation dynamics and their interplay with chromatin states and...
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