Zhongyou Li

Variance-based global sensitivity analysis [46] was employed to quantitatively evaluate the influence of hepatic vascular properties on cardiac hemodynamics, including cardiac output (CO), mean aortic pressure (MAP), and stroke work (SW). Four hepatic parameters were selected for this analysis: Rpv-d, Rha-d, Rhs, and hepatic venous resistance Rhv.

Abstract Although tobramycin increases lung function in people with cystic fibrosis (pwCF), the density of Pseudomonas aeruginosa (P. aeruginosa) in the lungs is only modestly reduced by tobramycin; hence, the mechanism whereby tobramycin improves lung function is not completely understood. Here, we demonstrate that tobramycin increases 5′ tRNA-fMet halves in outer membrane vesicles (OMVs) secreted by laboratory and CF clinical isolates of P. aeruginosa.

Abstract Nonsense-mediated mRNA decay (NMD) is a network of pathways that degrades transcripts that undergo premature translation termination. In mammals, NMD can be divided into the exon junction complex (EJC)-enhanced and EJC-independent branches. Fluorescence- and luminescence-based reporters have long been effective tools to investigate NMD, yet existing reporters largely focus on the EJC-enhanced pathway.