Zhouweiyu Chen

Abstract Functional RNA plays a crucial role in regulating cellular processes throughout the life cycle of a cell. Identifying functional changes at each stage, from inception to development to maturation, functional execution, and eventual death or pathological transformation, often requires systematic comparisons of functional expression across cell populations.

Abstract Almost inevitably, mature cells meet their demise through specific processes of phenotypic change such as apoptosis. Although single-cell RNA sequencing (scRNA-seq) technology can reconstruct processes like life cycles and disease progression, identifying specific types of cell death in dying cells remains challenging due to the complexity of related signaling pathways and marker genes.