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Zhouyuan Shen

As seen in: BioRxiv
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Articles

Polo-like kinase 1 maintains transcription and chromosomal accessibility during mitosis

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By Zhouyuan Shen, Kristin Adams, Ryan Moreno, Robert F. Lera
| BioRxiv
Abstract Transcription persists at low levels in mitotic cells and plays essential roles in mitotic fidelity and chromosomal dynamics. However, the detailed regulatory network of mitotic transcription remains largely unresolved. Here, we report the novel role of Polo-like kinase 1 (Plk1) in maintaining mitotic transcription. Using 5-ethynyl uridine (5-EU) labeling of nascent RNAs, we found that Plk1 inhibition leads to significant downregulation of nascent transcription in prometaphase cells.
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Dynamic Plk1 recruitment to the inner centromere

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By Robert F. Lera, Roshan X Norman, Anuoluwapo A Mattix, Zhouyuan Shen
| BioRxiv
Abstract Mitosis is carefully orchestrated by reversible phosphorylation events. Polo-like kinase 1 (Plk1) regulates multiple functions across the kinetochore during mitotic progression. Recently, Bub1 (outer kinetochore) and CENP-U (inner kinetochore) were described as two major sites of Plk1 recruitment to the kinetochore. Here, we report an additional dynamic site of Plk1 recruitment to the inner centromere.
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