Zhulian Li

Abstract The poor structural stability and insufficient endogenous activation of cartilaginous implant might be key factors for cartilage regeneration after microfracture. Herein, inspired by the restrictive effect of collagen fibers on proteoglycans, we develop artificial proteoglycan assemblies (DSPG@Pep) through sequential co-assembly of bioactive polysaccharide, protein and peptides via electrostatic interactions and covalent conjugation.

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma70544-sup-0001-SuppMat.docx13.9 MB Supporting Information adma70544-sup-0002-Video1.mp438.3 MB Supplemental Video 1 adma70544-sup-0003-Video2.mp48 MB Supplemental Video 2 References 1, , , , Nat. Rev. Chem. 2021, 5, 773. 2, , Immunity 2021, 54, 2439. 3, , , , , , , , , Bioact Mater 2024, 40, 597. 4, , , , , Blood 2001, 97, 3691. 5, , , , , , , , Nat. Mater. 2010, 10, 61.

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