Zhuo Yin

Abstract Bladder cancer (BLCA) is a lethal malignancy with limited therapeutic options. The role of the transcription factor Engrailed-1 (EN1) in BLCA metabolic reprogramming was previously unknown. Our study demonstrates that EN1 is significantly overexpressed in BLCA, correlating with poor patient survival and driving tumor progression. Mechanistically, EN1 transcriptionally upregulates the deubiquitinase USP18.

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1. Introduction This paper aims to systematically study the ecological impact of phytoplankton’s carbon nutrition strategy on the carbon cycle and sequestration in the aquatic environment, including dividing and summarizing the main carbon utilization strategies of phytoplankton in three aspects (carbon acquisition, carbon metabolism, and carbon emission) and assessing its impact on carbon flux at the water–air interface.