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Xuebijing injection mitigates instant blood−mediated inflammatory reaction and enhances intrahepatic islet transplantation via target NF−κB pathway
Introduction Islet transplantation has emerged as a promising therapeutic option for type 1 diabetes (T1D), offering the potential for insulin independence and improved glycemic control (1, 2). Despite these promising outcomes, the success of intrahepatic islet transplantation is often compromised by a complex and detrimental immune response known as the instant blood-mediated inflammatory reaction (IBMIR), a severe immune response that occurs immediately post-transplantation (3).
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