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Zi-Yin Yang on Muck Rack

Zi-Yin Yang

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Articles

Sensitive monitoring of enhancer and noncoding RNA transcription via ribozyme-assisted RNA editing

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By Jing L. Wang, Jia-Zhen Wang, Lu-Feng Hu, Yu-Ting Zhao, Gang Xie, Yi-Xia Wu, Boyan Zhao, Huiqing Cao, Yangming Wang, Zi-Yin Yang
| Nature Verified
Abstract Understanding transcriptional regulation of native genomic elements requires tools that combine high sensitivity, quantitative output, and broad applicability. Existing methods often have limited dynamic range, disrupt host RNAs, or fail to detect short-lived transcripts. Here, we present ribozyme-processed ADAR-engaging RNA-directed editing (REDDIT), a technology that converts transcriptional events into reporter protein translation via precise A-to-I RNA editing.
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