Zi-Ying Wang

CIN chromosomal instability DDR DNA damage response DMEM Dulbecco's modified Eagle's medium FBS fetal bovine serum GO Gene Ontology HGSOC high-grade serous ovarian carcinoma IHC immunohistochemical KEGG Kyoto Encyclopedia of Genes and Genomes KO knockout PFA paraformaldehyde qRT-PCR quantitative real-time PCR SA-β-gal senescence-associated β-galactosidase SETX senataxin WT wild-type 1 Introduction Ovarian cancer, particularly high-grade serous carcinoma (HGSOC), is a leading cause of...

Abstract Dysfunctional autophagy, a key cellular cleaning process, is a key driver of brain ageing and neurodegenerative diseases such as Alzheimer’s disease (AD). However, developing effective treatments by enhancing autophagy has been challenging, as most known compounds act through the broad mTOR pathway, risking side effects, and few can effectively penetrate the brain.

Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.