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Zi-yuan Gao on Muck Rack

Zi-yuan Gao

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MMP14-mediated proteolytic cleavage of LAMC2 domain III fragment drives osimertinib resistance in EGFR-mutant non-small cell lung cancer

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By Di Wu, Hao-Yue Yu, Yong He, Cong-hua Lu, Wan-da Bi, Zi-yuan Gao, Dai-juan Huang, Cai-yu Lin
| Nature Verified
Abstract Acquired resistance to osimertinib remains a critical clinical challenge in EGFR-mutant non-small cell lung cancer (NSCLC), with 40%–60% of progressing patients lacking an identifiable genetic resistance driver. Through quantitative secretomic profiling of paired osimertinib-sensitive and -resistant NSCLC cell lines, we identified laminin subunit γ2 (LAMC2) as markedly enriched in resistant cell secretomes.
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