Ziam Khan on Muck Rack

Ziam Khan

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Articles

Characterization of membrane structures regulating primary ciliogenesis by quantitative isotropic ultrastructure imaging

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By Quanlong Lu, Huijie Zhao, Erina Kamiya, Valentin Magidson, Sumeth Perera, Kedar Narayan, Christopher J Westlake, Ziam Khan, Adam Harned, Abhi Senthilkumar, Avaneesh Kilnagar
| Nature Verified
Abstract The trafficking, docking, and fusion of membrane vesicles at the mother centriole (MC) are important for primary cilium construction. Here, we determined the three-dimensional (3D) membrane ultrastructures, and associated proteins, involved in this primary cilium assembly mechanism upstream of axoneme growth. Our work suggests that the enlargement of small vesicles docked to the MC is a key trigger for ciliogenesis progression, a process requiring the MC distal appendage protein CEP164.
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