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Zidao Wang

As seen in: Nature, BioRxiv
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Articles

Mesenchymal-epithelial transition supports rapid repair of the endometrial epithelium during postpartum uterine regeneration

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By Zidao Wang, Kimberly M. Davenport, Susanta K. Behura, Amanda Patterson, Jonathas Medeiros de Almeida
| Nature Verified
Abstract Postpartum endometrial re-epithelialization is vital for uterine homeostasis and fertility, but mechanisms of this process are poorly understood. Using lineage-tracing mice and single-nucleus RNA-sequencing, we detail the process of mesenchymal-epithelial transition (MET) in endometrial re-epithelialization. Mesenchymal-derived (MD) epithelial cells arise quickly during repair and express genes related to cell adhesion, cytoskeletal remodeling, and epithelial barrier function.
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Mesenchymal-epithelial transition serves to rapidly, yet transiently, restore the endometrial epithelium during postpartum murine uterine regeneration

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By Kimberly M. Davenport, Susanta K. Behura, Amanda Patterson, Zidao Wang
| BioRxiv
Abstract The uterus is a remarkable organ in its ability to undergo extensive tissue damage during menstruation and parturition, yet achieves efficient, scar-free repair. Coordinated regulation of this regenerative process is essential for uterine homeostasis and fertility; however, the underlying mechanisms remain incompletely understood.
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