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Abstract Atrial fibrillation (AF) recurrence following radiofrequency ablation (RFA) remains a significant clinical challenge, and pacemaker implantation may influence outcomes. However, the underlying molecular mechanisms are not well understood. This study aimed to investigate whether pacemaker implantation is statistically associated with of AF recurrence and to identify proteomic biomarkers associated with this statistical relationship.
1 Introduction The increasing incidence of age-related diseases worldwide, such as cardiovascular diseases, cancers, and neurodegeneration, imposes a substantial decrease in human lifespan (Campisi et al. 2019; Guo et al. 2022; López-Otín et al. 2023). Conventional medical research predominantly focuses on organ-specific diseases, disregarding the pathogenic processes of the entire human body that impact lifespan.
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