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Abstract A rational design for facilitating innovative cell death modes can substantially aid advances in antitumour therapy1,2. Here we design and implement a unique mode of immunogenic membranolytic cell death (mLCD) in tumour cells, characterized by time-lagged rupture from the lysosomal to plasma membranes; this approach was found to robustly potentiate immune checkpoint blockade therapy.
4. Discussion The present study analyzed the results of 624 Chinese patients obtained for a retrospective cohort study where each participant underwent aortic surgery for STAAAD. We found, for the first time, that preoperative serum albumin was conversely related to the hazard of AKI in the presence of less than 32 g/L among Chinese patients even after adjustment for significant confounding factors before surgery and perioperatively.
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